Development of a mouse bile-duct cannulated model for use in DMPK studies

SOT 2025 -- The use of surgical models can provide valuable information on the absorption and metabolism of new drug candidates over a continual time course. The mouse (Mus musculus), including genetically modified models, is a commonly used laboratory animal. In preclinical safety assessment studies (toxicology, metabolism, pharmacology and pharmacokinetic studies), the mouse is the most common alternative rodent species to the rat. The mouse can offer physiological or metabolic characteristics that are more relevant to the human condition than the rat. The objectives of this initiative were to: Further develop a mouse bile duct-cannulated (BDC) model and characterise the routes and rates of excretion of total radioactivity in urine, faeces and bile, following oral administration of a radiolabelled test article (5 mL/kg) to intact and biliary cannulated mice.