Ophthalmology
Advance your ophthalmic program with unmatched expertise in ocular safety assessment, pharmacology, and DMPK.
No matter what your ophthalmic therapy or device, we can support your program with strategic guidance and expert study execution. We offer comprehensive ophthalmic drug development services with proven success across therapeutic indications including rare diseases, ophthalmic devices and cell and gene therapy programs.
In partnership with Ocular Services on Demand (OSOD) in the US, and STZ Eyetrial in Germany, we offer state of the art capabilities and world class ophthalmic expertise, including bespoke consultations and advice from study design to data analysis.
Full suite of animal models for ophthalmology
- Mouse
- Rat
- Rabbit (Dutch Belted and New Zealand White)
- Canine
- NHP (Cynomolgus Macaque)
- Gottingen Minipig
Pharmacology models, as well as model transfer and validation
- Wet AMD model – Laser induced CNV in NHP
- Glaucoma model – photocoagulation of trabecular meshwork in NHP
- Transgenic rodent models of genetic conditions
- Immunodeficient rodent models for cell therapy programs
Clinical ocular dose routes available in most models
- Topical
- Intravitreal (including rodent)
- Subretinal (including rodent)
- Suprachoroidal
- Intracameral
- Implants (subretinal, intracameral, intravitreal)
- Surgical techniques (e.g. vitrectomy, lens replacement)
- Novel and bespoke dosing approaches
Ophthalmoscopy conducted by board certified veterinary ophthalmologists using standardized techniques and lexicon widely accepted by regulators
- Indirect Ophthalmoscopy
- Slit Lamp Biomicroscopy
- Gonioscopy
- Standard and bespoke scoring systems (SPOTS, Hackett McDonald, SUN, etc.)
- Corneal Fluorescein Staining
- Intraocular Pressure Measurement (applanation and rebound tonometry)
- Esthesiometry
- Corneal Pachymetry
Advanced imaging capabilities and expert analysis
- Fundus Photography
- Fundus Autofluorescence Imaging
- Fluorescein Angiography
- Slit Lamp Photography
- Noncontact Specular Microscopy
- Confocal Corneal Biomicroscopy
- Optical Coherence Tomography (Spectral Domain and Anterior Segment)
- Confocal Scanning Laser Ophthalmoscopy
- Gonioscopy Photography
Retinal electrophysiology capabilities with protocols optimized for species and study goals
- Scotopic and Photopic Full Field Electroretinography
- Multi-focal Electroretinography
- Pattern Electroretinography
- Visual Evoked Potential
Comprehensive ocular pathology
- Species- and study-specific histology techniques for ocular tissues
- Board certified veterinary pathologists with ophthalmology expertise
- Standard and special staining techniques
- Immunohistochemistry
Pharmacokinetic and Biodistribution studies
- Specialized ocular tissue and sample collection
- Extensive ocular tissue lists and analytical capabilities
- LC/MS-MS
- ELISA analysis
- qPCR and RT-qPCR
- Radioanalysis
- Quantitative autoradiography
- Microautoradiography
From study direction to dose formulation, in-life to necropsy and histology, dedicated and experienced Labcorp ocular teams execute every phase of your study and advise on factors critical to success.