Patient-derived xenograft (PDX) models
Improve your therapeutic efficacy predictions with our fully characterized patient-derived xenografts (PDX) representing multiple histotypes.
Access model data today
PDX models provide a clinically relevant platform for preclinical testing by better predicting how therapies will perform in human patients, enhancing the likelihood of success in clinical trials, and ultimately leading to the development of more effective and personalized treatment for cancer.
Growing portfolio of recently collected and fully characterized PDXs to advance personalized medicine approaches
Choose from over 300 models originating within the last 7 years for a more accurate reflection of human cancer biology compared to older or less relevant models. Our growing portfolio of models range multiple histotypes and biomarkers.
Cancer types include:
- Brain
- Breast
- Cholangio/Bile duct
- Colorectal
- Gastric
- Head and neck
- Lung
- Mesothelioma
- Neuroendocrine
- Ovarian
- Pancreatic
- Renal
- Skin
- Sarcoma
- Uveal
Biomarkers include, but not limited to:
- Claudin 6
- TROP2
- EGFR
- HER2
- KRAS
- CCNE1
- BRCA1/2
- MUC16
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Disease-relevant PDXs representing multiple histotypes
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Extensive molecular and gene expression characterization in addition to treatment history
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Tumor models fresh from the clinic at low passage
Fully characterized for enhanced utility and improved translatability
Proper characterization ensures your data is reproducible and reliable to drive go/no go decision making.
Our models have extensive molecular characterization including:
- Genomic, molecular and phenotypic data
- Tumor growth curves and histopathology data
- Relevant patient information and treatment history
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Maximize the insights gained from PDX Models
Our optimized PDX engraftment procedures and modern technologies, such as multi-omics, digital spatial analysis and biodistribution, provide comprehensive insights into their molecular landscape. To utilize the unique genomic features of PDX models we offer a broad range of in vivo and ex vivo analysis capabilities. Our solutions include a variety of therapeutic approaches including adoptive cell therapies and combination therapies with radiation and radiopharmaceuticals to support your oncology research program.
Oncology experience you can count on
With more than 10,000 studies completed, we have amassed extensive experience and deep insights to inform end-to-end discovery oncology research. Our team can help:
- Explore the effects of drugs and biologics using both human and syngeneic tumor models.
- Empower you to make more informed decisions at every step of the development process.
- Support you with testing throughout the entire development journeyopens in a new tab, including bioanalysis, pharmacology, toxicology, companion diagnostics, central labs, and more.
- Gain efficiencies as we connect insights effectively from one stage to the next.