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Synonyms
- DHEA
- Unconjugated DHEA
Expected Turnaround Time
4 - 6 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Related Documents
For more information, please view the literature below.
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection
If a red-top tube is used, transfer separated serum to a plastic transport tube.
Storage Instructions
Sample must be refrigerated due to limited stability at room temperature. Freeze if unable to maintain refrigerated.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 6 hours |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Shipped or received in lab at room temperature
Test Details
Use
Evaluate adrenal carcinomas that frequently secrete large amounts of DHEA
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Reference Interval
See table.1,2
Age (y) | Range (ng/dL) |
|---|---|
0 to 5 | 0−67 |
6 to 7 | 0−110 |
8 to 10 | 0−185 |
11 to 12 | 0−201 |
13 to 14 | 0−318 |
15 to 16 | 39−481 |
17 to 19 | 40−491 |
20 to 50 | 31−701 |
>50 | 21−402 |
Additional Information
Dehydroepiandrosterone (DHEA) is a steroid that is produced by both the adrenal cortex and the testis.3 The levels of this steroid increase before the onset of puberty (adrenarche) and decrease significantly with age.4 DHEA and DHEA-S are the major precursors of 17-ketosteroids.
Footnotes
1. Ducharme JR, Forest MG, De Peretti E, et al. Plasma adrenal and gonadal sex steroids in human pubertal development. J Clin Endocrinol Metab. 1976; 42(3):468-476. 130382
2. Tietz NW, ed. Clinical Guide to Laboratory Tests. 3rd ed. Philadelphia, Pa: WB Saunders Co;1995:195-196.
3. de Peretti E, Forest M. Unconjugated dehydroepiandrosterone plasma levels in normal subjects from birth to adolescence in humans: The use of a sensitive radioimmunoassay. J Clin Endocrinol Metab. 1976; 43(5):982-991. 186482
4. Carlstrom K, Brady S, Lunell NO, et al. Dehydroepiandrosterone sulphate and dehydroepiandrosterone in serum: Differences related to age and sex. Maturitas. 1988; 10(4):297-306.2976116
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 004100 | DHEA, Serum | 2193-1 | 070355 | Dehydroepiandrosterone (DHEA) | ng/dL | 2193-1 |
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