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Antidiuretic Hormone (ADH) Profile

Test Number 046557
Test number copied
CPT 83930; 84588
Synonyms
  • ADH
  • Arginine Vasopressin
  • AVP
  • Vasopressin

Test Details

Methodology

ADH: radioimmunoassay (RIA); osmolality: freezing point depression

Result Turnaround Time

4 - 10 days

Use

Aid in the diagnosis of urine concentration disorders, especially diabetes insipidus, syndrome of inappropriate ADH (SIADH), psychogenic water intoxication, and syndromes of ectopic ADH production

Specimen Requirements

Test Includes

ADH; osmolality

Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

References

Cowley AW Jr, Cushman WC, Quillen EW Jr, et al. Vasopressin elevation in essential hypertension and increased responsiveness to sodium intake. Hypertension. 1981; 3(3 Pt 2):I93-100. 7262983
Malvin RL. Possible role of the renin-angiotensin system in the regulation of antidiuretic hormone secretion. Fed Proc. 1971; 30(4):1383-1386. 4326738
Pullan PT, Clappison BH, Johnston CI. Plasma vasopressin and human neurophysins and physiological and pathological states associated with changes in vasopressin secretion. J Clin Endocrinol Metab. 1979; 49(4):580-587. 479348

Custom Additional Information

ADH, produced in the supraoptic and paraventricular locations of the hypothalamus, acts on the collecting tubules of the kidney to cause increase in permeability to water and urea. ADH release is triggered by a number of both osmotic and nonosmotic stimuli. Measurement of ADH is useful in separating central diabetes insipidus, which is marked by polydipsia and polyuria and is caused by inadequate ADH production from nephrogenic diabetes insipidus caused by the inability of renal tubules to respond to ADH. In SIADH, release of ADH is disproportionate to a low serum osmolality. SIADH results due to a number of conditions such as pulmonary disease, head trauma, and cancer.

Specimen

Serum, refrigerated and plasma, frozen

Volume

1 mL serum and 2 mL plasma

Minimum Volume

0.5 mL serum and 1 mL plasma (Note: This volume does not allow for repeat testing.)

Container

Gel-barrier tube and lavender-top (EDTA) tube

Storage Instructions

Freeze plasma immediately. Refrigerate serum.

Causes for Rejection

Recently administered isotopes; plasma specimen not received frozen

Collection Instructions

Draw serum and plasma samples and separate from cells using a refrigerated centrifuge. Transfer separated samples into clearly labeled “plasma” and “serum” plastic transport tubes. Freeze plasma immediately and refrigerate serum. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Reference Range

• ADH: 0.0−4.7 pg/mL

• Osmolality:

− Neonates: May be as low as 266 mOsmol/kg

− 0 to 60 years: 275−295 mOsmol/kg

− >60 years: 280−301 mOsmol/kg

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
046557 Antidiuretic Hormone Profile 010449 ADH pg/mL 3126-0
046557 Antidiuretic Hormone Profile 002071 Osmolality mOsmol/kg 2692-2
Order Code046557
Order Code NameAntidiuretic Hormone Profile
Order Loinc
Result Code010449
Result Code NameADH
UofMpg/mL
Result LOINC3126-0
Order Code046557
Order Code NameAntidiuretic Hormone Profile
Order Loinc
Result Code002071
Result Code NameOsmolality
UofMmOsmol/kg
Result LOINC2692-2